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Operating on a patient with an uncorrected B12 deficiency increases the risk of: Impaired wound healing and a higher chance of wound breakdown Post-operative fatigue and slower recovery, particularly if anaemia is also present Elevated homocysteine, which feeds into an already elevated DVT risk profile A sub-optimal immune response during the early wound healing phase None of these is certain to happen

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Moreover, there are differences in laboratory assessment methods in different trials, as well as differences in intra assay coefficient of variation (intra-assay CV) and inter-assay coefficient of variation (inter-assay CV)

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